- Title
-
Tgfb3 collaborates with PP2A and Notch signaling pathways to inhibit retina regeneration
- Authors
- Lee, M., Wan, J., Goldman, D.
- Source
- Full text @ Elife
pSmad3 expression in the uninjured and injured retina. |
Alk5-dependent pSmad3 expression. |
Injury-dependent regulation of tgfb gene expression. |
tgfb3 expression in developing and adult retina. |
Tgfb3 knockdown and tgfb3 gene editing do not affect MG differentiation. |
Tgfb3 suppresses MG proliferation and reprogramming gene expression. |
tgfb3 gene expression in hsp70:tgfb3 fish. |
Tgfb1b and Tgfb3 stimulate pSmad3 expression, but only Tgfb3 inhibits injury-dependent MG proliferation. |
Heat shock induced tgfb1b gene expression in hsp70:tgfb1b fish. |
Alk5 and PP2A inhibition rescues Tgfb3-mediated inhibition of MG proliferation in the injured retina.PHENOTYPE:
|
Tgfb3 acts upstream of Notch signaling to inhibit MG proliferation. |