FIGURE

Figure 5

ID

ZDB-FIG-200530-29

Publication

Lee et al., 2020 - Tgfb3 collaborates with PP2A and Notch signaling pathways to inhibit retina regeneration

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Figure 5

Tgfb1b and Tgfb3 stimulate pSmad3 expression, but only Tgfb3 inhibits injury-dependent MG proliferation.

(A) Top illustration is experimental time line. Bottom panels show BrdU immunofluorescence on retinal sections from uninjured and injured, heat shock-treated Wt, hsp70:tgfb1b, and hsp70:tgfb3 transgenic fish. (B) Quantification of data in (A). (C) pSmad3 immunofluorescence on retinal sections from uninjured and injured, heat shock-treated Wt, hsp70:tgfb1b, and hsp70:tgfb3 transgenic fish. Arrowheads point to the INL at the injury site. Asterisk marks the injury site. White dot in two right-hand panels marks non-specific autofluorescence in the photoreceptor layer. Scale bar is 50 microns. Error bars are SD. **p<0.01.

Expression Data

Antibody:	Ab2-smad3
Fish:	WT mi50Tg mi51Tg
Condition:	heat shock, surgical manipulation: retina
Anatomical Term:	Muller cell
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT mi50Tg mi51Tg
Condition:	heat shock, surgical manipulation: retina
Observed In:	Muller cell retina cell population proliferation
Stage:	Adult

Phenotype Detail

Acknowledgments

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