Gene
dll4
- ID
- ZDB-GENE-041014-73
- Name
- delta-like 4 (Drosophila)
- Symbol
- dll4 Nomenclature History
- Previous Names
-
- si:ch211-244p18.5
- zgc:136596
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable Notch binding activity. Involved in negative regulation of sprouting angiogenesis and negative regulation of vascular endothelial cell proliferation. Acts upstream of or within several processes, including negative regulation of blood vessel endothelial cell migration; vasculature development; and ventral spinal cord interneuron differentiation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including atrioventricular canal endocardium; brain; endothelial cell; vasculature; and xanthophore. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome. Orthologous to human DLL4 (delta like canonical Notch ligand 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 67 figures from 54 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 35 figures from 26 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Adams-Oliver syndrome 6 | 616589 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR013032 | EGF-like, conserved site |
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001774 | Delta/Serrate/lag-2 (DSL) protein |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR011651 | Notch ligand, N-terminal domain |
| Family | IPR050906 | Notch signaling pathway |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
Domain Details Per Protein
| Protein | Length | Delta/Serrate/lag-2 (DSL) protein | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like, conserved site | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | Notch ligand, N-terminal domain | Notch signaling pathway |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q1ECY3
|
683 |
Interactions and Pathways
No data available
Plasmids