Gene

crlf1a

ID

ZDB-GENE-040718-397

Name

cytokine receptor-like factor 1a

Symbol

crlf1a Nomenclature History

Previous Names

clf-1a (1)
crlf1
fd24a10
wu:fd24a10
zgc:91992 (1)

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have cytokine binding activity and cytokine receptor activity. Predicted to localize to external side of plasma membrane and receptor complex. Human ortholog(s) of this gene implicated in cold-induced sweating syndrome 1. Is expressed in diencephalon; hypothalamus; optic tectum; and telencephalon. Orthologous to human CRLF1 (cytokine receptor like factor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from 7 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:91992 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With crlf1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
cold-induced sweating syndrome 1	Alliance	Cold-induced sweating syndrome 1	272430

Associated With crlf1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003961	Fibronectin type III
Domain	IPR010457	Immunoglobulin C2-set-like, ligand-binding
Domain	IPR015152	Growth hormone/erythropoietin receptor, ligand binding
Family	IPR050379	Type I Cytokine Receptor
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036116	Fibronectin type III superfamily
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily