Gene
ascl1a
- ID
- ZDB-GENE-980526-90
- Name
- achaete-scute family bHLH transcription factor 1a
- Symbol
- ascl1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Exhibits sequence-specific DNA binding activity. Predicted to contribute to DNA-binding transcription factor activity. Involved in several processes, including animal organ development; epithelial cell differentiation; and regulation of gene expression. Predicted to localize to RNA polymerase II transcription factor complex. Human ortholog(s) of this gene implicated in congenital central hypoventilation syndrome. Is expressed in several structures, including digestive system; nervous system; neural tube; neuronal stem cell; and optic cup. Orthologous to human ASCL1 (achaete-scute family bHLH transcription factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 152 figures from 93 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu887 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 9 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | E-box Binding Transcriptional Regulators | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain |
|---|---|---|---|---|
|
UniProtKB:Q90259
|
196 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ascl1a-201
(1)
|
Ensembl | 1,977 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-ascl1 | polyclonal | Rabbit |
|
Sigma-Aldrich
|
3 |
Plasmids
No data available