FIGURE

Fig. 7

ID

ZDB-FIG-240916-123

Publication

Williams et al., 2024 - Keratin 8/18a.1 Expression Influences Embryonic Neural Crest Cell Dynamics and Contributes to Postnatal Corneal Regeneration in Zebrafish

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Fig. 7

Retinoic acid regulates krt18a.1, but not krt8, expression in the eye during early embryogenesis. (A–F) Treatment of Casper zebrafish embryos at 24 and 27 hpf with DEAB and RA, respectively, followed by wholemount colorimetric in situ analysis shows decreased krt18a.1, but not krt8, expression in the developing eye in response to pharmacological insult. (G) Quantification of these effects, as measured in the anterior chamber (orange dashed box) and hyaloid (yellow dashed box) regions of the eyes of 48-hpf zebrafish, further shows that compared with the DMSO vehicle control, treatment with either DEAB or ATRA significantly decreased krt18a.1 expression, while that of krt8 was not affected. *, p-value < 0.05.

Expression Data

Genes:	krt8 krt18a.1
Fish:	mitfa^w2/w2; mpv17^a9/a9
Conditions:	chemical treatment by environment: all-trans-retinoic acid chemical treatment by environment: 4-(diethylamino)benzaldehyde
Anatomical Term:	eye
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mitfa^w2/w2; mpv17^a9/a9
Conditions:	chemical treatment by environment: all-trans-retinoic acid chemical treatment by environment: 4-(diethylamino)benzaldehyde
Observed In:	eye
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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