FIGURE

Figure 7

ID

ZDB-FIG-200725-26

Publication

Toms et al., 2020 - Clinical and preclinical therapeutic outcome metrics for USH2A-related disease

Other Figures

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Figure 7

Auditory function in ush2a^u507 larvae. (A) and (B) Macular hair cell cross-sections from 6 days post fertilization (dpf) wt and ush2a^u507 larvae were immunostained with anti-acetylated tubulin (red), anti-usherin-N (green) and DAPI (blue). (C) and (D) Stereociliary hair bundles of the anterior macula in wt and ush2a^u507 zebrafish at 6 days post fertilization stained with Alexa Fluor 647 Phalloidin. Bar graph (E) shows the number of hair cell bundles per anterior macula in wt and ush2a^u507 larvae (mean ± SEM, n = 10). Bar graph (F) shows distance moved in response to acoustic stimuli of different frequencies (mean ± SEM, n ≥ 77 from three biological replicates per group). An unpaired t-test or two-way ANOVA were used to test for statistical significance. ^*P < 0.05. Scale bars = 10 μm.

Expression Data

Gene:	ush2a
Antibody:	Ab2-ush2a
Fish:	AB ush2a^{zf3378/zf3378} (AB)
Anatomical Term:	macula stereocilium bundle
Stage:	Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ush2a^{zf3378/zf3378} (AB)
Observed In:	anterior macula stereocilium bundle macula stereocilium bundle startle response
Stage Range:	Day 5 to Day 6

Phenotype Detail

Acknowledgments

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