FIGURE

Figure 6

ID

ZDB-FIG-200725-25

Publication

Toms et al., 2020 - Clinical and preclinical therapeutic outcome metrics for USH2A-related disease

Other Figures

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Figure 6

Visual function in ush2a^u507 zebrafish. (A) Normalized average b-wave amplitude of ERG responses recorded from wt and ush2a^u507 zebrafish at 5 days post fertilization (wt: n = 69, ush2a^u507: n = 67). (B) Maximum b-wave amplitudes are plotted as bar graphs (mean ± SEM). (C) Visual acuity (cycles per degree, cpd) of wt and ush2a^u507 zebrafish at 3 months post fertilization (mpf), 6 mpf and 12 mpf, assessed using the optokinetic response assay (n = 4–5, mean ± SEM). ^*^*P < 0.001. Mann Whitney tests and two-way ANOVA were used to test for statistical significance in ERG and optokinetic response data, respectively.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ush2a^{zf3378/zf3378} (AB)
Observed In:	visual perception
Stage Range:	Day 5 to Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Hum. Mol. Genet.