FIGURE

Fig. 6.

ID

ZDB-FIG-191230-617

Publication

Tomecka et al., 2019 - Clinical pathologies of bone fracture modelled in zebrafish

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Fig. 6.

Genetic ablation of osteoclasts reduces bone callus resorption. (A,B) TRAP staining of fractures in WT (A) and csf1ra^j4e1 mutants (B) at given time points following crush. (C) The area of TRAP staining was significantly reduced in the mutants at all time points (n=12). (D,E) Fluorescent images of WT (D) and csf1ra^j4e1 mutant (E) fractures stained with calcein. The time points following crush are given. (F) Relative callus width measurements at different time points for fractures of WT and csf1ra mutants at given time points (n=15). By 42 hpc, the mutants had significantly fewer remodelled calluses. *P<0.05, **P<0.01, ***P<0.001; ANOVA with Sidak post test. Scale bars: in B and D, 100 µm for A,B,D,E.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	csf1ra^j4e1/j4e1
Condition:	compression injury: caudal fin lepidotrichium
Observed In:	bone remodeling osteoclast
Stage:	Adult

Phenotype Detail

Acknowledgments

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