FIGURE

Fig. 5.

ID

ZDB-FIG-191230-616

Publication

Tomecka et al., 2019 - Clinical pathologies of bone fracture modelled in zebrafish

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Fig. 5.

Alendronate reduces osteoclast activity but not numbers at the fracture. (A) Images of fractures processed by in situ hybridisation for ctsk to label osteoclasts at the fracture site at 1 dpc, following 14 h pulse exposure to various concentrations of alendronate, as shown. (B) TRAP staining performed at 4 dpc, following 14 h alendronate treatment at various concentrations immediately prior to fracture. (C) Reduced areas of TRAP staining were quantified (n=12). ***P<0.0001; ANOVA with Tukey post test. Scale bars: 100 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Condition:	chemical treatment by environment: alendronate sodium trihydrate, compression injury: caudal fin lepidotrichium
Observed In:	bone remodeling osteoclast
Stage:	Adult

Phenotype Detail

Acknowledgments

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