FIGURE

Fig. 2.

ID

ZDB-FIG-191230-613

Publication

Tomecka et al., 2019 - Clinical pathologies of bone fracture modelled in zebrafish

Other Figures

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Fig. 2.

Non-union fractures in a zebrafish OI model. (A-D) Brightfield images at low (A,B) and high (C,D) magnification of adult fins at 3 months post fertilisation, showing thickening and dark foci in frf mutants (B,D) compared with WT (A,C). (E,F) Magnified images of WT (E) and frf (F) foci stained with Alizarin Red demonstrates bone calluses at these sites, indicating fractures. (G,H) Brightfield and fluorescent images of induced fractures in WT (G) and frf (H) at the indicated dpc. Bone was alternately stained with calcein (green) or Alizarin Red (red) to visualise callus growth. (I) A proportion of induced fractures in frf were non-union; n=12 per genotype. (J) The gap size following fracture was not reduced compared with WT over time; n=12 per point. **P<0.01, ***P<0.001; ANOVA with Sidak post test. Scale bars: in B, 2 mm for A,B; in D and F, 200 µm for C-F; in H, 100 µm for G,H.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	bmp1a^tp34/tp34
Condition:	compression injury: caudal fin lepidotrichium
Observed In:	bone mineralization callus formation caudal fin lepidotrichium caudal fin lepidotrichium regenerating tissue
Stage:	Adult

Phenotype Detail

Acknowledgments

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