Search Ontology:
GO: Biological Process

bone remodeling

Term ID
GO:0046849
Synonyms
  • bone remodelling
Definition
The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.
References
Ontology
GO: Biological Process    QuickGO    AmiGO
Relationships
has parts
is a type of
negatively regulated by
positively regulated by
regulated by
Phenotype
Phenotype caused by Genes