ZFIN Image: Tomecka et al., 2019, Fig. 5.

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Fig. 5.

Alendronate reduces osteoclast activity but not numbers at the fracture. (A) Images of fractures processed by in situ hybridisation for ctsk to label osteoclasts at the fracture site at 1 dpc, following 14 h pulse exposure to various concentrations of alendronate, as shown. (B) TRAP staining performed at 4 dpc, following 14 h alendronate treatment at various concentrations immediately prior to fracture. (C) Reduced areas of TRAP staining were quantified (n=12). ***P<0.0001; ANOVA with Tukey post test. Scale bars: 100 µm.

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Acknowledgments

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