FIGURE

Fig. 3

ID

ZDB-FIG-110322-56

Publication

van der Velden et al., 2011 - The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Fig. 3

lkb1 mutants exhibit hallmarks of response to starvation and high metabolic rate. (A) Transverse vibratome sections of PAS-stained WT and lkb1-mutant livers at 5 and 7 dpf. At 7 dpf the WT liver still contains a moderate amount of glycogen, but glycogen is depleted in the lkb1-mutant liver. (B) Transverse vibratome sections of ORO-stained WT and lkb1-mutant livers on days indicated. Note strong lipid accumulation in the lkb1-mutnt liver at 7 dpf and in starved WT liver at 11 dpf. (C) Lkb1 mutants exhibit high metabolic rate. Histograms depict acid production rates of WT and lkb1-mutant larvae at different days of development. The rate of acid production correlates with metabolic rate and was calculated as described in SI Materials and Methods.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT stk11^{hu1968/hu1968}
Condition:	fasting
Observed In:	liver metabolic process whole organism
Stage Range:	Day 6 to Days 7-13

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA