FIGURE

Fig. S4

ID

ZDB-FIG-110322-62

Publication

van der Velden et al., 2011 - The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish

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Fig. S4

Intestinal lipid processing is intact in lkb1-mutant larvae. Fluorescent live images of WT larvae (A and C) and lkb1-mutant larvae (B and D) incubated with 0.3 g/mL N-{[6-(2,4- dinitrophenyl)amino]hexanoyl}-1-palmitoyl-2-BODIPY-FL-pentanoyl-sn-glycero-3-phosphoethanolamine (PED6) for 2 h. Lateral views, anterior to the right. Cleavage of PED6 by phospholipase A2 (PLA2) relieves intramolar quenching and results in increased fluorescence. Gall bladder fluorescence (arrow in all panels) is observed because of rapid transport through the intestine and hepatobilary systems. In lkb1-mutant larvae, fluorescence in both the intestinal lumen and gall bladder was detected at levels equivalent to those in WT larvae.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA