FIGURE

Fig. 8

ID

ZDB-FIG-240313-22

Publication

Auman et al., 2023 - Zebrafish smarcc1a mutants reveal requirements for BAF chromatin remodeling complexes in distinguishing the atrioventricular canal from the cardiac chambers

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Fig. 8

Normal initiation of gene expression in the chamber myocardium of smarcc1a mutants. Whole-mount in situ hybridization compares expression patterns of nppa (A–D) and bmp10 (E, F) expression at 36 (A, B) or 48 (C–F) hpf. Dorsal views, ventricle to the top. (A, B) The initial expression of nppa is similar in wild-type and smarcc1a mutant hearts at 36 hpf. (C, D) At 48 hpf, wild-type expression of nppa is found in the chamber myocardium but not in the AVC (arrowhead). In smarcc1a mutants, elevated expression is seen throughout the heart, including in the AVC (arrowhead). (E, F) In both wild-type and smarcc1a mutant hearts at 48 hpf, bmp10 expression is found in the cardiac chambers (arrow), with a clear gap in expression at the AVC.

Expression Data

Genes:	bmp10 notch1b nppa
Fish:	smarcc1a^sk29/sk29 tnnt2a^b109/b109 smarcc1a^sk29/sk29; tnnt2a^b109/b109
Anatomical Terms:	heart presumptive atrium heart tube peripheral region presumptive cardiac ventricle heart tube peripheral region
Stage Range:	Prim-25 to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	smarcc1a^sk29/sk29 tnnt2a^b109/b109 smarcc1a^sk29/sk29; tnnt2a^b109/b109
Observed In:	heart
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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