FIGURE

Figure 5

ID

ZDB-FIG-210130-20

Publication

Brunal et al., 2021 - Effects of Constitutive and Acute Connexin 36 Deficiency on Brain-Wide Susceptibility to PTZ-Induced Neuronal Hyperactivity

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Figure 5

Whole-brain activity map showing significant regional differences following Cx36 blocking drug mefloquine and PTZ exposure in wild-type zebrafish larvae. Dorsal and lateral view of zebrafish larvae brain. (A–D) Images show regions with significantly increased (green) or decreased (magenta) activity compared to DMSO and embryo medium (vehicle) treated fish (n = 9). (A) 2 mM PTZ (n = 10). (B) 5 mM PTZ (n = 10) (C) 10 mM PTZ (n = 10). (D) 20 mM PTZ (n = 10). (E–H) Images show regions with significantly increased (green) or decreased (magenta) activity compared to mefloquine and embryo medium (vehicle) treated fish (n = 9). (E) 2 mM PTZ (n = 10). (F) 5 mM PTZ (n = 8). (G) 10 mM PTZ (n = 10). (H) 20 mM PTZ (n = 10). (I–M) Images show regions with significantly increased (green) or decreased (magenta) activity in mefloquine treated fish, compared to DMSO (vehicle) treated fish. (I) embryo medium (0 mM PTZ) (n = 9). (J) 2mM PTZ (n = 10). (K) 5 mM PTZ (DMSO n = 10, mefloquine n = 8) (L) 10 mM PTZ (n = 10). (M) 20 mM PTZ (n = 10). Mef: mefloquine.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mitfa^w2/w2
Conditions:	chemical treatment by environment: Mefloquine hydrochloride chemical treatment by environment: Mefloquine hydrochloride chemical treatment by environment: pentetrazol
Observed In:	cerebellum neuronal action potential dorsal telencephalon neuronal action potential hindbrain neuronal action potential hypothalamus neuronal action potential olfactory bulb neuronal action potential optic tectum neuronal action potential pretectum neuronal action potential tegmentum neuronal action potential telencephalon neuronal action potential ventral telencephalon neuronal action potential
Stage:	Day 6

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Mol. Neurosci.