ZFIN Image: Brunal et al., 2021, Figure 5

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Figure Caption

Figure 5

Whole-brain activity map showing significant regional differences following Cx36 blocking drug mefloquine and PTZ exposure in wild-type zebrafish larvae. Dorsal and lateral view of zebrafish larvae brain. (A–D) Images show regions with significantly increased (green) or decreased (magenta) activity compared to DMSO and embryo medium (vehicle) treated fish (n = 9). (A) 2 mM PTZ (n = 10). (B) 5 mM PTZ (n = 10) (C) 10 mM PTZ (n = 10). (D) 20 mM PTZ (n = 10). (E–H) Images show regions with significantly increased (green) or decreased (magenta) activity compared to mefloquine and embryo medium (vehicle) treated fish (n = 9). (E) 2 mM PTZ (n = 10). (F) 5 mM PTZ (n = 8). (G) 10 mM PTZ (n = 10). (H) 20 mM PTZ (n = 10). (I–M) Images show regions with significantly increased (green) or decreased (magenta) activity in mefloquine treated fish, compared to DMSO (vehicle) treated fish. (I) embryo medium (0 mM PTZ) (n = 9). (J) 2mM PTZ (n = 10). (K) 5 mM PTZ (DMSO n = 10, mefloquine n = 8) (L) 10 mM PTZ (n = 10). (M) 20 mM PTZ (n = 10). Mef: mefloquine.

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Phenotype details

Acknowledgments

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