FIGURE

Figure 4

ID

ZDB-FIG-210130-19

Publication

Brunal et al., 2021 - Effects of Constitutive and Acute Connexin 36 Deficiency on Brain-Wide Susceptibility to PTZ-Induced Neuronal Hyperactivity

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Figure 4

Wild type whole-brain immunostaining Cx36 expression map in E3 vs. PTZ treated zebrafish larvae. Dorsal and lateral view of zebrafish larvae brain. Whole-brain expression of Cx36 using an anti-Cx36 antibody and tERK. Cyan indicates increases in Cx36 labeling in PTZ treated fish, and red indicated decreases in Cx36 labeling in PTZ treated fish. (A) After 30 min of 20 mM PTZ exposure (n = 10). (B) After 1 h of 20 mM PTZ exposure (n = 10). (C) 1-h recovery after PTZ is removed, n = 12. (D) 3 h of recovery after PTZ is removed, n = 12. (E) 6 h of recovery after PTZ is removed, n = 12. (F) 24 h of recovery after PTZ is removed, n = 10. (G) A graph depicting the number of activated caspase-3 positive cells in the rhombencephalon, mesencephalon, telencephalon, and diencephalon in wild-type fish with treatment with embryo medium (vehicle) (Black) or PTZ (Red). Data were analyzed using an unpaired t-test with Holm-Sidak's correction for multiple comparisons, n = 9.

Expression Data

Antibody:	Ab3-gjd2
Fish:	mitfa^w2/w2
Condition:	chemical treatment by environment: pentetrazol
Anatomical Terms:	cerebellum diencephalon hindbrain rhombomere 7 optic tectum
Stage:	Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mitfa^w2/w2
Condition:	chemical treatment by environment: pentetrazol
Observed In:	cerebellum diencephalon diencephalon apoptotic process hindbrain apoptotic process hindbrain rhombomere 7 midbrain apoptotic process optic tectum telencephalon apoptotic process
Stage:	Day 6

Phenotype Detail

Acknowledgments

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