FIGURE

Figure 4

ID

ZDB-FIG-210128-117

Publication

Fish et al., 2021 - Venous Thrombosis and Thrombocyte Activity in Zebrafish Models of Quantitative and Qualitative Fibrinogen Disorders

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Figure 4

fga exon 2 skipping. (A) A scheme to highlight changes in fga exon 2 genomic DNA in red (gDNA) led to exon 2 skipping after transcription and splicing. A partial cDNA sequence to show the exon 1 to exon 3 splicing is shown. (B) Immunoblotting of plasma samples from fga^+/+, fga^+/Δ19–56, and fga^{Δ19–56/Δ19–56} fish with anti-ceruloplasmin and anti-fibrinogen Aα chain antibodies. (C) Amino acid alignment of the predicted fibrinogen Aα chains resulting from the human FGA IVS2+3insCAT mutation and the zebrafish fga^Δ19–56 mRNA. The junction of exon 1- and exon 3-encoded amino acids are in bold and underlined for each chain.

Expression Data

Genes:	cp fga
Antibodies:	Ab1-fga Ab2-cp
Fish:	TU fga^ug704/ug704 (TU) fga^ug704/+ (TU)
Anatomical Term:	blood plasma
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	fga^ug704/ug704 (TU)
Observed In:	blood plasma
Stage:	Adult

Phenotype Detail

Acknowledgments

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