Gene

fga

ID

ZDB-GENE-031010-21

Name

fibrinogen alpha chain

Symbol

fga Nomenclature History

Previous Names

sb:cb892
wu:fa55c12
wu:fb20e08
wu:fb59b03
wu:fi39d04
zgc:92117

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have signaling receptor binding activity. Involved in blood coagulation, fibrin clot formation. Predicted to localize to fibrinogen complex. Human ortholog(s) of this gene implicated in congenital afibrinogenemia; familial visceral amyloidosis; and thrombophilia. Is expressed in liver and yolk syncytial layer. Orthologous to human FGA (fibrinogen alpha chain).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

21 figures from 13 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb892 (5 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fga Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital afibrinogenemia	Alliance	Afibrinogenemia, congenital	202400
familial visceral amyloidosis	Alliance	Amyloidosis, hereditary systemic 2	105200
		Dysfibrinogenemia, congenital	616004
		Hypodysfibrinogenemia, congenital	616004

Associated With fga Via Experimental Models

Human Disease	Fish	Conditions	Citations
congenital afibrinogenemia	fga^ug703/ug703 (AB)	standard conditions	Fish et al., 2014
congenital afibrinogenemia	fga^ug701/ug701 (AB)	standard conditions	Fish et al., 2014
congenital afibrinogenemia	fga^ug702/ug702 (AB)	standard conditions	Fish et al., 2014
vascular hemostatic disease	fga^{mi4007/mi4007} (AB/TL)	standard conditions	Hu et al., 2019

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020837	Fibrinogen, conserved site
Domain	IPR002181	Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
Domain	IPR012290	Fibrinogen, alpha/beta/gamma chain, coiled coil domain
Homologous_superfamily	IPR014716	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
Homologous_superfamily	IPR036056	Fibrinogen-like, C-terminal

Domain Details Per Protein

Protein	Length	Fibrinogen, alpha/beta/gamma chain, coiled coil domain	Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1	Fibrinogen, conserved site	Fibrinogen-like, C-terminal
UniProtKB:B8A5L6 InterPro	684

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	fga-201 (1) Ensembl	Ensembl	2,366 nt	Select Tool
mRNA	fga-203 (1) Ensembl	Ensembl	2,469 nt	Select Tool
ncRNA	fga-003 (1) Ensembl	Ensembl	690 nt	Select Tool
ncRNA	fga-004 (1) Ensembl	Ensembl	768 nt	Select Tool
ncRNA	fga-005 (1) Ensembl	Ensembl	751 nt	Select Tool
ncRNA	fga-006 (1) Ensembl	Ensembl	503 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-fga	polyclonal	fga	IgG	Rabbit	WB		3

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations