FIGURE

Figure 6

ID

ZDB-FIG-210128-119

Publication

Fish et al., 2021 - Venous Thrombosis and Thrombocyte Activity in Zebrafish Models of Quantitative and Qualitative Fibrinogen Disorders

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Figure 6

Thrombocyte adhesion and aggregation in a hypodysfibrinogenemia model. (A) Fluorescent thrombocyte binding and adhesion in 5 dpf Tg(itga2b:EGFP) embryos after laser injury of the PCV over time in fga^+/+, fga^+/Δ19–56 and fga^{Δ19–56/Δ19–56} genotypes. Each line represents the mean (+/−SEM) of thrombocyte fluorescence reaching a threshold fluorescence within a defined area. (B) Time lapse images of fga^+/+ and fga^{Δ19–56/Δ19–56} larvae upon (0 s) and 180 s after laser injury. Fluorescence from the laser is seen at 0 s and where green fluorescent thrombocytes accumulate at 180 s. The dorsal aorta (DA), posterior cardinal vein (PCV) and site of laser injury (LI, arrows) are indicated.

Expression Data

Gene:	EGFP
Fish:	la2Tg (TU) fga^ug704/+; la2Tg (TU) fga^ug704/ug704; la2Tg (TU)
Condition:	light damage: posterior caudal vein
Anatomical Term:	thrombocyte
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	fga^ug704/ug704 (TU) fga^ug704/+ (TU)
Condition:	light damage: posterior caudal vein
Observed In:	posterior caudal vein blood coagulation, fibrin clot formation posterior caudal vein platelet aggregation
Stage:	Day 5

Phenotype Detail

Acknowledgments

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