Gene

cp

ID

ZDB-GENE-010522-1

Name

ceruloplasmin

Symbol

cp Nomenclature History

Previous Names

cer (1)
wu:fi23f10 (1)

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to enable oxidoreductase activity. Predicted to be involved in iron ion homeostasis and iron ion transport. Predicted to act upstream of or within copper ion transport. Located in cytoplasm and nucleus. Is expressed in several structures, including blood plasma; digestive system; liver and biliary system; male organism; and yolk syncytial layer. Human ortholog(s) of this gene implicated in aceruloplasminemia; epilepsy; and hemosiderosis. Orthologous to human CP (ceruloplasmin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

97 figures from 62 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55445 (8 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Choksi et al., 2014
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cp Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
aceruloplasminemia	Alliance	Aceruloplasminemia	604290

Associated With cp Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR002355	Multicopper oxidase, copper-binding site
Conserved_site	IPR033138	Multicopper oxidases, conserved site
Domain	IPR011706	Multicopper oxidase, C-terminal
Domain	IPR011707	Multicopper oxidase-like, N-terminal
Domain	IPR048236	Ceruloplasmin-like, fifth cupredoxin domain
Family	IPR050633	Neuropilin/Multicopper Oxidase/Coagulation Factor
Homologous_superfamily	IPR008972	Cupredoxin

Domain Details Per Protein

Protein	Length	Ceruloplasmin-like, fifth cupredoxin domain	Cupredoxin	Multicopper oxidase, copper-binding site	Multicopper oxidase, C-terminal	Multicopper oxidase-like, N-terminal	Multicopper oxidases, conserved site	Neuropilin/Multicopper Oxidase/Coagulation Factor
UniProtKB:Q7ZU12 InterPro	1087

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cp-201 (1) Ensembl	Ensembl	3,590 nt	Select Tool ZFIN BLAST
mRNA	cp-202 (1) Ensembl	Ensembl	619 nt	Select Tool ZFIN BLAST
mRNA	cp-203 (1) Ensembl	Ensembl	620 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab2-cp	polyclonal	cp		Rabbit	WB	EUROGENTEC S.A.	1
Ab1-cp	polyclonal	cp		Rabbit	WB	AnaSpec	3

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations