FIGURE

Figure 8

ID

ZDB-FIG-210128-121

Publication

Fish et al., 2021 - Venous Thrombosis and Thrombocyte Activity in Zebrafish Models of Quantitative and Qualitative Fibrinogen Disorders

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Figure 8

Fluorescent thrombocyte binding and aggregation after PCV laser injury in fga^−/− larvae with transgenic AαE or AαE R28C expression: a model of dysfibrinogenemia. (A) A scheme representing the experimental setup. Early Tg(itga2b:EGFP), fga^−/− embryos were microinjected with Tol2 transgenesis plasmids for expression of fibrinogen AαE or AαE R28C, AαE + AαE R28C or a half quantity of AαE (AαE ½). Tol2 transposase mRNA was also present in injection mixes (not shown). (B) Fluorescent thrombocyte binding and adhesion at 5 dpf were monitored for each experimental group over time after PCV laser injury. Each line represents the mean fluorescence (+/−SEM). The number of larvae per group is shown in brackets.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	fga^ug701/ug701
Condition:	light damage: posterior caudal vein
Observed In:	posterior caudal vein blood coagulation, fibrin clot formation posterior caudal vein platelet aggregation
Stage:	Day 5

Phenotype Detail

Acknowledgments

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