FIGURE

Fig. 8

ID

ZDB-FIG-200207-8

Publication

Tian et al., 2020 - Systemic loss of Sarm1 protects Schwann cells from chemotoxicity by delaying axon degeneration

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Fig. 8

The clearance of the severed axons is not essential for neuronal-circuit repair.

a, b Confocal images of wild type (a) and Sarm1−/− (b) specimens expressing EGFP in sensory neurons of the lateral line (green) and stained with the monoclonal antibody 6D2. Stainings were performed at indicated time points after axons severing (hpi). The arrows point to the cutting sites. Scale bar is 50 μm. c Live imaging of the Tg[Mbp-EGFP; SILL:mCherry] after severing. The arrows indicated the fragmented axons and the arrowheads the fragmented myelin. Scale bar 20 μm. d Live imaging of the Sarm1−/− in Tg[Mbp-EGFP; SILL:mCherry] after severing. Arrows indicate regrowing axons, and arrowheads indicate the juxtaposition between the regrowing axons. Scale bar 20 μm.

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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