FIGURE

Fig 8

ID

ZDB-FIG-200206-8

Publication

Hin et al., 2020 - Accelerated brain aging towards transcriptional inversion in a zebrafish model of the K115fs mutation of human PSEN2

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Fig 8

Cells expressing L-plastin are more abundant across the heterozygous mutant (<italic>psen1</italic><sup><italic>K97fs/+</italic></sup>) zebrafish brain than in wild type siblings at 24 months.

Immunostaining for the pan-leukocyte marker L-plastin supports increased numbers of microglia in the forebrain (A-B), midbrain (C-D) and hindbrain (E-F). Increased microglial abundance is evident in psen1^K97fs/+ heterozygotes in both ventricular (D.i, F.i) and parenchymal (D.ii) regions compared to wild types (C, E). (G) Significant differences in MFI were observed between the forebrain, midbrain and hindbrain of psen1K97fs/+ and psen1+/+ fish; **p = 0.0048, ***p = 0.0005, ****p < 0.0001; two-way ANOVA with Sidak’s multiple comparisons test. Data presented as means with SEM. Scale bar 50 μm in all images.

Expression Data

Antibody:	Ab2-lcp1
Fish:	TU psen1^uaa10/+
Anatomical Terms:	forebrain microglial cell hindbrain microglial cell midbrain microglial cell
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	psen1^uaa10/+
Observed In:	forebrain microglial cell hindbrain microglial cell midbrain microglial cell
Stage:	Adult

Phenotype Detail

Acknowledgments

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