FIGURE

Fig 7

ID

ZDB-FIG-200206-7

Publication

Hin et al., 2020 - Accelerated brain aging towards transcriptional inversion in a zebrafish model of the K115fs mutation of human PSEN2

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Fig 7

Module overlap between co-expression networks constructed using zebrafish and human brain gene expression data.

Zebrafish and human co-expression networks were constructed using 7,118 genes that were orthologs in zebrafish and humans and expressed in brain gene expression data. Modules of co-expressed genes were separately identified for both the zebrafish and human co-expression networks, resulting in 30 modules in the zebrafish network (left) and 27 modules in the human network (right). Several zebrafish modules (indicated with asterisks) were found to have Z-summary preservation score > 2, indicating statistically significant weak-to-moderate preservation of these modules (i.e. genes in these modules still tend to be co-expressed) in the human brain co-expression network. Four out of five of these modules also showed statistically significant functional enrichment. See Table 1 for more details on the Z-summary preservation scores and functional enrichment for each module in the zebrafish co-expression network.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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