FIGURE

Fig. 11

ID

ZDB-FIG-170901-11

Publication

Gau et al., 2017 - An ancient neurotrophin receptor code; a single Runx/Cbfβ complex determines somatosensory neuron fate specification in zebrafish

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Fig. 11

trkC1+ neurons switch fate to become trkB1+ neurons in the cbfb mutant zebrafish.

A-F, Optical sections of double fluorescent in situ hybridization for runx3 (red) and trkB1 (green) (A-B), runx3 (red) and trkC1 (green) (C-D), and trkC1 (red) and trkB1 (green) (E-F) in wild-type and cbfb mutants. G-I, Optical sections of antibody staining of GFP (green) in conjunction with fluorescent in situ hybridization for runx3 (G) in trpa1b:GFP fish at 3dpf. H, Representations of 3dpf wild-type and cbfb mutant somatosensory subpopulations as a percent of the whole TG. Dashed white line outline green cells; Dashed yellow lines outline red cells; Arrowhead indicates double positive cells. Scale bar: 20μm. Embryos per condition (n = 3–4). All error bars represent S.E.M.

Expression Data

Genes:	EGFP ntrk2a ntrk3a runx3
Fish:	WT cbfb^w128/w128 (AB) a129Tg
Anatomical Term:	trigeminal ganglion
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cbfb^w128/w128 (AB)
Observed In:	trigeminal ganglion
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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