Gene
ntrk3a
- ID
- ZDB-GENE-010126-3
- Name
- neurotrophic tyrosine kinase, receptor, type 3a
- Symbol
- ntrk3a Nomenclature History
- Previous Names
-
- trkC1 (1)
- si:ch73-236b16.1
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to have neurotrophin binding activity; neurotrophin receptor activity; and transmembrane receptor protein tyrosine kinase activity. Involved in central nervous system development and negative regulation of apoptotic process. Predicted to localize to axon; integral component of plasma membrane; and receptor complex. Human ortholog(s) of this gene implicated in pancreatic cancer. Is expressed in nervous system and otic vesicle. Orthologous to human NTRK3 (neurotrophic receptor tyrosine kinase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Conserved_site | IPR002011 | Tyrosine-protein kinase, receptor class II, conserved site |
| Domain | IPR000483 | Cysteine-rich flanking region, C-terminal |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR031635 | Growth factor receptor NTRK, leucine rich repeat C-terminal |
| Family | IPR020777 | Growth factor receptor NTRK |
| Family | IPR050122 | Receptor Tyrosine Kinase |
| Family | IPR050958 | Cell Adhesion and Cytoskeletal Organization |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
Domain Details Per Protein
| Protein | Length | Cell Adhesion and Cytoskeletal Organization | Cysteine-rich flanking region, C-terminal | Growth factor receptor NTRK | Growth factor receptor NTRK, leucine rich repeat C-terminal | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, receptor class II, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:G9JKB3
|
576 | ||||||||||||||||||
|
UniProtKB:F1QKJ0
|
818 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ntrk3a-201
(1)
|
Ensembl | 3,475 nt | ||
| mRNA |
ntrk3a-202
(1)
|
Ensembl | 13,332 nt |
Interactions and Pathways
No data available
Plasmids
No data available