Gene
ntrk3a
- ID
- ZDB-GENE-010126-3
- Name
- neurotrophic tyrosine kinase, receptor, type 3a
- Symbol
- ntrk3a Nomenclature History
- Previous Names
-
- trkC1 (1)
- si:ch73-236b16.1
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable neurotrophin binding activity; neurotrophin receptor activity; and transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within central nervous system development and negative regulation of apoptotic process. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in axon and plasma membrane. Is expressed in nervous system and otic vesicle. Human ortholog(s) of this gene implicated in adenoid cystic carcinoma; colorectal cancer; and stomach cancer. Orthologous to human NTRK3 (neurotrophic receptor tyrosine kinase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Conserved_site | IPR002011 | Tyrosine-protein kinase, receptor class II, conserved site |
| Domain | IPR000483 | Cysteine-rich flanking region, C-terminal |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR031635 | Growth factor receptor NTRK, leucine rich repeat C-terminal |
| Family | IPR020777 | Growth factor receptor NTRK |
| Family | IPR050122 | Receptor Tyrosine Kinase |
| Family | IPR050958 | Cell Adhesion and Cytoskeletal Organization |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
Domain Details Per Protein
| Protein | Length | Cell Adhesion and Cytoskeletal Organization | Cysteine-rich flanking region, C-terminal | Growth factor receptor NTRK | Growth factor receptor NTRK, leucine rich repeat C-terminal | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, receptor class II, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:G9JKB3
|
576 | ||||||||||||||||||
|
UniProtKB:F1QKJ0
|
818 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ntrk3a-201
(1)
|
Ensembl | 3,475 nt | ||
| mRNA |
ntrk3a-202
(1)
|
Ensembl | 13,332 nt |
Interactions and Pathways
No data available
Plasmids
No data available