Gene
ntrk2a
- ID
- ZDB-GENE-010126-1
- Name
- neurotrophic tyrosine kinase, receptor, type 2a
- Symbol
- ntrk2a Nomenclature History
- Previous Names
-
- trkB1 (1)
- si:ch211-148p15.2
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable brain-derived neurotrophic factor binding activity and brain-derived neurotrophic factor receptor activity. Predicted to be involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; positive regulation of neuron projection development; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to act upstream of or within cell differentiation; nervous system development; and protein phosphorylation. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in axon and plasma membrane. Is expressed in endoderm; mesoderm; nervous system; neural tube; and pharyngeal epithelium. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; autistic disorder; developmental and epileptic encephalopathy 58; heroin dependence; and morbid obesity. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 58 | Alliance | Developmental and epileptic encephalopathy 58 | 617830 |
| Obesity, hyperphagia, and developmental delay | 613886 |
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
| Protein | Additional Resources | Length |
|---|---|---|
| UniProtKB:A0A8M3B589 | InterPro | 787 |
| UniProtKB:A0A8M3AVL1 | InterPro | 791 |
| UniProtKB:A0A8M3B2B0 | InterPro | 447 |
| UniProtKB:A0AB13A3P4 | InterPro | 791 |
| UniProtKB:A0AB32U0B8 | InterPro | 787 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ntrk2a-201
(1)
|
Ensembl | 2,343 nt | ||
| mRNA |
ntrk2a-202
(1)
|
Ensembl | 3,735 nt | ||
| ncRNA |
ntrk2a-002
(1)
|
Ensembl | 550 nt |
Interactions and Pathways
No data available
Plasmids
No data available