Gene
runx3
- ID
- ZDB-GENE-000605-2
- Name
- RUNX family transcription factor 3
- Symbol
- runx3 Nomenclature History
- Previous Names
-
- runxb
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in cartilage development; embryonic viscerocranium morphogenesis; and hemopoiesis. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in breast cancer (multiple); female reproductive organ cancer (multiple); in situ carcinoma; pancreatic cancer; and urinary bladder cancer. Is expressed in several structures, including Rohon-Beard neurons; digestive system; ganglia; oral epithelium; and skeletal element. Orthologous to human RUNX3 (RUNX family transcription factor 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR013524 | Runt domain |
| Domain | IPR013711 | Runx, C-terminal domain |
| Family | IPR000040 | Acute myeloid leukemia 1 protein (AML1)/Runt |
| Family | IPR016554 | Runt-related transcription factor RUNX |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR012346 | p53/RUNT-type transcription factor, DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Acute myeloid leukemia 1 protein (AML1)/Runt | p53-like transcription factor, DNA-binding domain superfamily | p53/RUNT-type transcription factor, DNA-binding domain superfamily | Runt domain | Runt-related transcription factor RUNX | Runx, C-terminal domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q9DEA0
|
424 |
Interactions and Pathways
No data available
Plasmids
No data available