FIGURE

Fig. S19

ID

ZDB-FIG-141007-60

Publication

Bielczyk-Maczyńska et al., 2014 - A loss of function screen of identified genome-wide association study Loci reveals new genes controlling hematopoiesis

Other Figures

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Fig. S19

Differentiated thymic T-cells could be readily identified by rag1 expression when examined at 4 dpf. Whole mount in situ hybridization with a rag1 riboprobe revealed a severe decrease in the number of T lymphocytes in kalrn2, mfn2, pdia5 and psmd13 MO injected embryos in thymi (arrow) at 4 dpf. Knock down of akap10, kalrn1 and rcor1 caused a moderate decrease in T lymphocyte numbers. All the embryos are positioned anterior up and dorsal to the back.

Expression Data

Gene:	rag1
Fish:	WT WT + MO1-akap10 WT + MO1-brd3a WT + MO1-brf1a WT + MO1-brf1b WT + MO1-cfap251 WT + MO1-kalrna WT + MO1-kalrnb WT + MO1-pdia5 WT + MO1-psmd13 WT + MO1-satb1b WT + MO1-wasla WT + MO1-waslb WT + MO2-mfn2 WT + MO2-rcor1 WT + MO4-kif1b
Knockdown Reagents:	MO1-akap10 MO1-brd3a MO1-brf1a MO1-brf1b MO1-cfap251 MO1-kalrna MO1-kalrnb MO1-pdia5 MO1-psmd13 MO1-satb1b MO1-wasla MO1-waslb MO2-mfn2 MO2-rcor1 MO4-kif1b
Anatomical Term:	T cell
Stage:	Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-akap10 WT + MO1-kalrna WT + MO1-kalrnb WT + MO1-pdia5 WT + MO1-psmd13 WT + MO2-mfn2 WT + MO2-rcor1
Knockdown Reagents:	MO1-akap10 MO1-kalrna MO1-kalrnb MO1-pdia5 MO1-psmd13 MO2-mfn2 MO2-rcor1
Observed In:	T cell
Stage:	Day 4

Phenotype Detail

Acknowledgments

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