FIGURE

Fig. 3

ID

ZDB-FIG-110128-10

Publication

Haud et al., 2011 - rnaset2 mutant zebrafish model familial cystic leukoencephalopathy and reveal a role for RNase T2 in degrading ribosomal RNA

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Fig. 3

Brain neurons of AO127 mutants contain lysosomes engorged with rRNA. Brain transverse sections from embryos 5 d after fertilization. EM revealed abundant electron-dense vesicles in the neurons of AO127 mutants (some of these are indicated by red arrowheads; Inset, electron-dense material is bounded by a limiting membrane). (Scale bars: 5 μm). In situ hybridization revealed accumulation of rRNA aggregates (white arrows) in the cytoplasm of AO127 mutant neurons. (Scale bars: 10 μm.)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	rnaset2^umc4/umc4
Observed In:	CNS neuron (sensu Vertebrata) lysosome rRNA catabolic process
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA