FIGURE

Fig. 4

ID

ZDB-FIG-110128-11

Publication

Haud et al., 2011 - rnaset2 mutant zebrafish model familial cystic leukoencephalopathy and reveal a role for RNase T2 in degrading ribosomal RNA

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Fig. 4

White matter anomalies in AO127 mutants. T₂-weighted MR images of the brain of WT and mutant AO127 adult zebrafish. Sagittal images indicate the presence of a white matter anomaly (white arrow) in telencephalon of mutant, which was not seen in WT. Coronal images show the presence of lesions adjacent to the ventricles (white arrow). IHC was carried out on the same samples used for MRI. Axonal disruptions around ventricles were seen using APP as a marker, as well as a higher number of astrocytes using GFAP as a marker, suggesting the presence of damaged neurons and inflammation around the lesions. (Scale bars: 1 mm for MR sagittal images, 500 μm for coronal images, 100 μm for immunohistochemistry.)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	rnaset2^umc4/umc4
Observed In:	brain white matter cerebral spinal fluid ventricular system ventricular zone ventricular zone astrocyte whole organism
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA