FIGURE

Fig. 6

ID

ZDB-FIG-060823-3

Publication

Walker et al., 2006 - Zebrafish furin mutants reveal intricacies in regulating Endothelin1 signaling in craniofacial patterning

Other Figures

All Figure Page

Back to All Figure Page

Fig. 6

furinA is required for early but not late edn1-dependent Dlx gene expression. Dlx expression in wild-type, furinA mutant, and edn1 mutant embryos at 30 hpf (A–L) and 36 hpf (M–U). (A–C) dlx2a, (D–F, M–O) dlx5a, (G–I, P–R) dlx6a, and (J–L, S–U) dlx3b. dlx2a expression is slightly affected in both furinA and edn1 mutant embryos, whereas expression of dlx3b, dlx5a, and dlx6a is moderately reduced in furinA mutants at 30 hpf and strongly reduced in edn1 mutants. Expression of dlx5a, dlx6a, and dlx3b recovers significantly in furinA mutants by 36 hpf. a1 and a2 label pharyngeal arch 1 and 2. Dotted lines label pharyngeal pouches 1 and 2 in (AU) and bottom of arch 1 and 2 in (O, R, and U). Scale bars: 50 μm.

Expression Data

Genes:	dlx2a dlx3b dlx5a dlx6a
Fish:	WT edn1^{tf216b/tf216b} furina^tg419/tg419
Anatomical Term:	pharyngeal arch
Stage Range:	Prim-15 to Prim-25

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 295(1), Walker, M.B., Miller, C.T., Talbot, J.C., Stock, D.W., and Kimmel, C.B., Zebrafish furin mutants reveal intricacies in regulating Endothelin1 signaling in craniofacial patterning, 194-205, Copyright (2006) with permission from Elsevier. Full text @ Dev. Biol.