Gene
dlx3b
- ID
- ZDB-GENE-980526-280
- Name
- distal-less homeobox 3b
- Symbol
- dlx3b Nomenclature History
- Previous Names
-
- dlx-3
- dlx3
- id:ibd3531 (1)
- wu:fb83f11
- zgc:91827
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Exhibits sequence-specific DNA binding activity. Involved in several processes, including sensory organ development; skeletal system development; and trigeminal nerve development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 4 and trichodontoosseous syndrome. Is expressed in several structures, including ectoderm; neural plate; neurogenic field; pharyngeal arch; and presumptive structure. Orthologous to human DLX3 (distal-less homeobox 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 258 figures from 175 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu221 (36 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| amelogenesis imperfecta type 4 | Alliance | Amelogenesis imperfecta, type IV | 104510 |
| trichodontoosseous syndrome | Alliance | Trichodontoosseous syndrome | 190320 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR000047 | Helix-turn-helix motif |
| Conserved_site | IPR017970 | Homeobox, conserved site |
| Domain | IPR001356 | Homeodomain |
| Domain | IPR020479 | Homeodomain, metazoa |
| Domain | IPR022135 | Distal-less-like homeobox protein, N-terminal domain |
| Family | IPR050460 | Distal-less homeobox transcription factors |
| Homologous_superfamily | IPR009057 | Homedomain-like superfamily |
Domain Details Per Protein
| Protein | Length | Distal-less homeobox transcription factors | Distal-less-like homeobox protein, N-terminal domain | Helix-turn-helix motif | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Homeodomain, metazoa |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q01702
|
269 | |||||||
|
UniProtKB:Q6DBS2
|
269 |
Interactions and Pathways
No data available
Plasmids
No data available