FIGURE

Fig. 1

ID

ZDB-FIG-070918-51

Publication

Walker et al., 2006 - Zebrafish furin mutants reveal intricacies in regulating Endothelin1 signaling in craniofacial patterning

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Fig. 1

furinA mutants have jaw and fin defects. (A and B) Live views at 5 dpf. furinA mutants have an open-mouth phenotype and fail to form a swim bladder (white asterisk in panel A). (C and D) Flat mounts of Alcian green-stained cartilages at 5 dpf. Wild-type DV joint regions are indicated with arrows in panel C. Fusions at joint regions in furinA mutants are indicated with asterisks in panel D. Cartilages are labeled as followed: pq (palatoquadrate), mc (Meckel's cartilage), hm (hyomandibula), ch (ceratohyal), sy (symplectic), and ih (interhyal). Two bones of the hyoid arch are also lightly stained with Alcian green: op (opercle), bsr_p (branchiostegal ray posterior). (E and F) Live views of the tail fin at 2 dpf. furinA mutant larvae have mildly ruffled fins. Scale bars: 50 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	furina^b963/b963 furina^{td204e/td204e} furina^tg419/tg419
Observed In:	branchiostegal ray 3 caudal fin ceratohyal cartilage hyosymplectic cartilage interhyal-epihyal joint mandibular arch skeleton joint Meckel's cartilage mouth opercle palatoquadrate cartilage pharyngeal arch 3 skeleton pharyngeal arch 4 skeleton swim bladder whole organism
Stage Range:	Long-pec to Day 5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 295(1), Walker, M.B., Miller, C.T., Talbot, J.C., Stock, D.W., and Kimmel, C.B., Zebrafish furin mutants reveal intricacies in regulating Endothelin1 signaling in craniofacial patterning, 194-205, Copyright (2006) with permission from Elsevier. Full text @ Dev. Biol.