ZFIN Image: Walker et al., 2006, Fig. 6

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Figure Caption

Fig. 6 furinA is required for early but not late edn1-dependent Dlx gene expression. Dlx expression in wild-type, furinA mutant, and edn1 mutant embryos at 30 hpf (A–L) and 36 hpf (M–U). (A–C) dlx2a, (D–F, M–O) dlx5a, (G–I, P–R) dlx6a, and (J–L, S–U) dlx3b. dlx2a expression is slightly affected in both furinA and edn1 mutant embryos, whereas expression of dlx3b, dlx5a, and dlx6a is moderately reduced in furinA mutants at 30 hpf and strongly reduced in edn1 mutants. Expression of dlx5a, dlx6a, and dlx3b recovers significantly in furinA mutants by 36 hpf. a1 and a2 label pharyngeal arch 1 and 2. Dotted lines label pharyngeal pouches 1 and 2 in (AU) and bottom of arch 1 and 2 in (O, R, and U). Scale bars: 50 μm.

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Expression / Labeling details

Acknowledgments

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Reprinted from Developmental Biology, 295(1), Walker, M.B., Miller, C.T., Talbot, J.C., Stock, D.W., and Kimmel, C.B., Zebrafish furin mutants reveal intricacies in regulating Endothelin1 signaling in craniofacial patterning, 194-205, Copyright (2006) with permission from Elsevier. Full text @ Dev. Biol.