Publication	Data		Fish	Anatomy
Feng et al., 2022	FIGURE 2		rnf2ihb806/ihb806; ihb807Tg (AB) ,   rnf2ihb806/ihb806 (AB)	brain phox2bb expression mislocalised, abnormal brain EGFP expression increased distribution, abnormal gut hand2 expression decreased distribution, abnormal gut phox2bb expression decreased distribution, abnormal gut ret expression decreased distribution, abnormal gut EGFP expression decreased distribution, abnormal gut neuron migration decreased process quality, abnormal
	FIGURE 3		rnf2ihb806/ihb806 (AB)	gut neuron decreased amount, abnormal
	FIGURE 4		rnf2ihb806/ihb806 (AB)	neural crest foxd3 expression decreased distribution, abnormal neural crest nes expression decreased distribution, abnormal neural crest sox1b expression mislocalised, abnormal neural crest sox1b expression spatial pattern, abnormal neural crest sox9b expression decreased distribution, abnormal neural plate border foxd3 expression decreased distribution, abnormal
	FIGURE 5		rnf2ihb806/ihb806 (AB)	neural crest cxcr4a expression decreased distribution, abnormal neural crest prdm1a expression spatial pattern, abnormal neural crest vgll2a expression decreased distribution, abnormal neural plate prdm1a expression decreased distribution, abnormal
	FIGURE 6		rnf2ihb806/ihb806 (AB)	eye phox2a expression decreased distribution, abnormal hindbrain tfap2a expression decreased distribution, abnormal midbrain neurod1 expression absent, abnormal midbrain tfap2a expression decreased distribution, abnormal midbrain hindbrain boundary egr2b expression decreased distribution, abnormal midbrain hindbrain boundary neurod1 expression absent, abnormal
	FIGURE 7		rnf2ihb806/ihb806 (AB)	central nervous system neurog1 expression decreased distribution, abnormal hindbrain neural rod cyp26c1 expression decreased distribution, abnormal hindbrain neural rod egr2b expression decreased distribution, abnormal midbrain hindbrain boundary neural rod pax2a expression decreased distribution, abnormal midbrain hindbrain boundary neural rod pax2a expression spatial pattern, abnormal
	FIGURE 8		rnf2ihb806/ihb806 (AB)	brain neuron differentiation decreased process quality, abnormal
Peng et al., 2021	Figure 1		rnf2ihb806/ihb806 (AB) ,   rnf2ihb808/ihb808 (AB)	atrioventricular canal increased width, abnormal atrioventricular valve morphology, abnormal atrioventricular valve structure, abnormal atrium fusiform, abnormal cardiac ventricle fusiform, abnormal eye decreased size, abnormal head morphology, abnormal heart heart contraction decreased process quality, abnormal heart morphology, abnormal pectoral fin absence of anatomical entity, abnormal pericardium edematous, abnormal whole organism Ab3-rnf2 labeling absent, abnormal
	Figure 2		rnf2ihb806/ihb806 (AB)	heart heart contraction decreased process quality, abnormal heart heart contraction decreased rate of occurrence, abnormal
	Figure 4		rnf2ihb806/ihb806 (AB)	heart myl7 expression spatial pattern, abnormal
	Figure 5		rnf2ihb806/ihb806; f1Tg (AB) ,   rnf2ihb806/ihb806 (AB)	cardiac muscle cell organization quality, abnormal cardiac muscle I band increased width, abnormal cardiac muscle Z disc increased width, abnormal heart acta1a expression increased amount, abnormal heart acta1b expression increased amount, abnormal heart acta2 expression increased amount, abnormal heart myh11a expression increased amount, abnormal heart myl1 expression decreased amount, abnormal heart myl9b expression increased amount, abnormal heart mylk2 expression increased amount, abnormal heart tnni2b.1 expression decreased amount, abnormal heart tnnt3a expression decreased amount, abnormal heart tube acta1a expression increased amount, abnormal heart tube acta2 expression decreased amount, abnormal heart tube acta2 expression increased amount, abnormal heart tube myh11a expression decreased amount, abnormal heart tube myh11a expression increased amount, abnormal heart tube myl1 expression increased amount, abnormal heart tube myl9b expression increased amount, abnormal heart tube mylk2 expression decreased amount, abnormal heart tube tnni2b.1 expression increased amount, abnormal heart tube tnnt3a expression increased amount, abnormal
	Figure 6		rnf2ihb806/ihb806 (AB)	atrioventricular canal alcama expression increased distribution, abnormal atrioventricular canal alcama expression spatial pattern, abnormal atrioventricular canal bmp4 expression spatial pattern, abnormal atrioventricular canal vcana expression increased distribution, abnormal atrioventricular canal vcana expression spatial pattern, abnormal cardiac conduction system decreased functionality, abnormal heart calcium-mediated signaling decreased process quality, abnormal sinoatrial node cardiac muscle cell decreased amount, abnormal
	text only		rnf2ihb806/ihb806 (AB) ,   rnf2ihb808/ihb808 (AB)	whole organism dead, abnormal
Chrispijn et al., 2019	Figure 1		rnf2ibl31/ibl31 (TL)	cardiac muscle cell myl7 expression spatial pattern, abnormal cranium morphology, abnormal exocrine pancreas prss1 expression decreased distribution, abnormal intestine fabp2 expression decreased distribution, abnormal liver fabp10a expression absent, abnormal pectoral fin absent, abnormal pericardium edematous, abnormal
	Figure 4		rnf2ibl31/ibl31; twu34Tg (TL)	heart EGFP expression spatial pattern, abnormal heart looping disrupted, abnormal
	Figure 6		rnf2ibl31/ibl31 (TL)	cardiac chamber development disrupted, abnormal heart myh6 expression spatial pattern, abnormal heart myh7 expression spatial pattern, abnormal heart myl7 expression spatial pattern, abnormal heart nppa expression spatial pattern, abnormal heart looping disrupted, abnormal
Lee et al., 2013	Fig. 7		WT + MO1-rnf2	retina cell apoptotic, abnormal retina intrinsic apoptotic signaling pathway by p53 class mediator increased occurrence, abnormal retina morphogenesis in camera-type eye disrupted, abnormal retina perforate, abnormal
van der Velden et al., 2013	Fig. 1		rnf2ibl31/ibl31 ,   rnf2ibl30/ibl30	embryonic neurocranium morphogenesis decreased process quality, abnormal embryonic viscerocranium morphogenesis decreased process quality, abnormal head lacks all parts of type ceratohyal cartilage, abnormal head lacks all parts of type ethmoid cartilage, abnormal head lacks all parts of type hyosymplectic cartilage, abnormal head lacks all parts of type Meckel's cartilage, abnormal head lacks all parts of type neurocranial trabecula, abnormal head lacks all parts of type palatoquadrate cartilage, abnormal head lacks all parts of type parachordal cartilage, abnormal pectoral fin lacks all parts of type mesocoracoid cartilage, abnormal pectoral fin lacks all parts of type scapulocoracoid, abnormal
	Fig. 2		rnf2ibl31/ibl31 ,   rnf2ibl30/ibl30	branchiomeric skeletal muscle development decreased process quality, abnormal head lacks all parts of type adductor mandibulae, abnormal head lacks all parts of type hyohyoideus, abnormal head lacks all parts of type interhyoideus, abnormal head lacks all parts of type sternohyoid, abnormal head lacks all parts of type ventral intermandibularis anterior, abnormal head lacks all parts of type ventral intermandibularis posterior, abnormal sternohyoid decreased size, abnormal
	Fig. 3		rnf2ibl31/ibl31 ,   rnf2ibl30/ibl30	melanocyte increased branchiness, abnormal xanthophore decreased branchiness, abnormal xanthophore decreased size, abnormal
	Fig. 4		rnf2ibl31/ibl31 ,   rnf2ibl30/ibl30	pharyngeal pouch cellular quality, abnormal
	Fig. 5		rnf2ibl31/ibl31 ,   rnf2ibl30/ibl30	chondrocyte differentiation decreased process quality, abnormal neurocranial trabecula chondrocyte undifferentiated, abnormal pharyngeal arch chondrocyte undifferentiated, abnormal
	Fig. 6		rnf2ibl31/ibl31 ,   rnf2ibl30/ibl30	cleithrum poorly ossified, abnormal direct ossification decreased process quality, abnormal endochondral ossification decreased process quality, abnormal opercle poorly ossified, abnormal parasphenoid poorly ossified, abnormal pharyngeal arch cartilage poorly ossified, abnormal
	Fig. 7		rnf2ibl31/ibl31 ,   rnf2ibl30/ibl30	pharyngeal arch apoptotic, abnormal post-vent region apoptotic, abnormal trunk apoptotic, abnormal
van der Velden et al., 2012	Fig. 1		rnf2ibl31/ibl31 ,   rnf2ibl30/ibl30	histone H2A ubiquitin ligase activity disrupted, abnormal pectoral fin absent, abnormal
	Fig. 3		rnf2ibl31/ibl31 ,   rnf2ibl30/ibl30	pectoral fin morphogenesis disrupted, abnormal
	Fig. 8		rnf2ibl31/ibl31 ,   rnf2ibl30/ibl30	pectoral fin absent, abnormal
	Fig. S3		rnf2ibl31/ibl31 ,   rnf2ibl30/ibl30	pectoral fin absent, abnormal pectoral fin morphogenesis disrupted, abnormal pericardium edematous, abnormal
	Fig. S4		WT + MO1-rnf2 ,   WT + MO2-rnf2	pectoral fin absent, abnormal pectoral fin morphogenesis disrupted, abnormal pericardium edematous, abnormal