FIGURE

Fig. 8

ID

ZDB-FIG-120601-79

Publication

van der Velden et al., 2012 - The Polycomb group protein Ring1b is essential for pectoral fin development

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Fig. 8

Restoration of mesenchymal gene expression and fin bud outgrowth in apc/ring1b mutants. (A-X) Dorsal views of embryos of the indicated genotypes stained for tbx5, fgf24 and fgf10 at 32 hpf (A-L) and 72 hpf (M-X). tbx5 (B,N), fgf24 (F,R) and fgf10 (J,V) are overexpressed in the apc pectoral fin mesenchyme at both 32 and 72 hpf. Expression of fgf24 (H) and fgf10 (L) is increased in apc/ring1b mutants compared with ring1b mutants (G,K) at 32 hpf. Expression of tbx5 (P), fgf24 (T) and fgf10 (X) is maintained in apc/ring1b mutants at 72 hpf. Arrowheads indicate staining at the fin bud region. (Y-BB) Lateral views of 72 hpf embryos of the indicated genotypes at the level of the pectoral fin. A rudimentary fin bud (outlined) is formed in apc/ring1b mutants at 72 hpf (BB).

Expression Data

Genes:	fgf10a fgf24 tbx5a
Fish:	WT apc^hu745/hu745 rnf2^ibl30/ibl30 rnf2^ibl31/ibl31 apc^hu745/hu745; rnf2^ibl30/ibl30 apc^hu745/hu745; rnf2^ibl31/ibl31
Anatomical Terms:	mesenchyme pectoral fin pectoral fin
Stage Range:	Prim-15 to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	apc^hu745/hu745 rnf2^ibl30/ibl30 rnf2^ibl31/ibl31 apc^hu745/hu745; rnf2^ibl30/ibl30 apc^hu745/hu745; rnf2^ibl31/ibl31
Observed In:	pectoral fin
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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