FIGURE

Fig. 6

ID

ZDB-FIG-241203-6

Publication

Volkov et al., 2024 - Samd7 represses short-wavelength cone genes to preserve long-wavelength cone and rod photoreceptor identity

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Fig. 6

The role of samd7 in zebrafish photoreceptor specification. Diagram of cone subtypes in the WT and samd7?/? zebrafish retina. In the samd7?/? retina, red cones are transformed into hybrid red/UV-sensitive cones, green cones are absent, blue cones are approximately doubled, and the number of rods is greatly reduced. We propose that Samd7 represses UV-cone-specific gene expression by repressing tbx2a and tbx2b, two key regulators of opn1sw1 expression (4, 11, 12) Activation is indicated with an arrowhead, and repression with a flat bar. Black coloring indicates that the factor is expressed, and gray indicates that it is not. A dashed line represents a proposed regulatory relationship and a solid line represents a previously verified regulatory function.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA