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Fig. 6 The role of samd7 in zebrafish photoreceptor specification. Diagram of cone subtypes in the WT and samd7?/? zebrafish retina. In the samd7?/? retina, red cones are transformed into hybrid red/UV-sensitive cones, green cones are absent, blue cones are approximately doubled, and the number of rods is greatly reduced. We propose that Samd7 represses UV-cone-specific gene expression by repressing tbx2a and tbx2b, two key regulators of opn1sw1 expression (4, 11, 12) Activation is indicated with an arrowhead, and repression with a flat bar. Black coloring indicates that the factor is expressed, and gray indicates that it is not. A dashed line represents a proposed regulatory relationship and a solid line represents a previously verified regulatory function.