FIGURE

Fig. 8

ID

ZDB-FIG-240903-122

Publication

Song et al., 2024 - Photoreceptor regeneration occurs normally in microglia-deficient irf8 mutant zebrafish following acute retinal damage

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Fig. 8

Regeneration after metronidazole-induced rod ablation in irf8;Tg(zOPS:ntrB-EGFP)gm500 animals. (A) Schematic illustrating experimental paradigm and treatment regimen. (B,C) Immunohistochemistry with anti-GFP antibodies (green) and EdU (magenta) on retinal cryosections from wild-type and irf8 mutants at 48 h post MTZ treatment or 30 days post MTZ treatment. MTZ treatment fully ablated rod photoreceptors and induced M�ller glia proliferation at 48 h post treatment and rod fully regenerated by 30 dpi. ROS rod outer segments, ONL outer nuclear layer, INL inner nuclear layer, RGC retinal ganglion cell layer. Scale bar, 50 ?m.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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