FIGURE

Fig. 1

ID

ZDB-FIG-240903-115

Publication

Song et al., 2024 - Photoreceptor regeneration occurs normally in microglia-deficient irf8 mutant zebrafish following acute retinal damage

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Fig. 1

Adult irf8 mutants have a significantly fewer retinal microglia. (A) 4C4 (magenta) and L-plastin (yellow) immunoreactivity in 6 mpf wild-type retinas to label microglia. (B) Immunohistochemistry of 3 mpf, 6 mpf, and 10 mpf wild-type (top row) and irf8 mutants (bottom row) with 4C4 (magenta) and L-plastin (yellow). (C?F) Quantification of 4C4+ cells in the inner plexiform layer (IPL) outer plexiform layer (OPL), subretinal space (SRS), and total retina of wild-type and irf8 mutants with age. Data are plotted as means � SD and p-values were generated by Welch?s ANOVA test with Dunnett?s T3 multiple comparisons test (ONL, SRS, total) or Kruskal?Wallis test with Dunn?s correction for multiple comparisons (INL). *p < 0.05, **p < 0.01, ***p < 0.005, ****p < 0.0001. SRS subretinal space, ONL outer nuclear layer, OPL outer plexiform layer, INL inner nuclear layer, IPL inner plexiform layer, RGC retinal ganglion cell layer. Scale bars, 50 ?m (A,B).

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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