FIGURE

Figure 12

ID

ZDB-FIG-240229-159

Publication

Chen et al., 2024 - Lactylation-driven FTO targets CDK2 to aggravate microvascular anomalies in diabetic retinopathy

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Figure 12

Schematic diagram of FTO-mediated effects on DR.

Driven by histone lactylation H3K18la, FTO up-regulation in ECs triggers vascular endothelial tip cell formation and its crosstalk with pericyte and microglia to aggravate diabetes-induced microvascular dysfunction. FTO mediates DR phenotypes via regulating CDK2 mRNA stability with YTHDF2 as the reader in an m⁶A-dependent manner.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ EMBO Mol. Med.