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Figure 12 Schematic diagram of FTO-mediated effects on DR.
Driven by histone lactylation H3K18la, FTO up-regulation in ECs triggers vascular endothelial tip cell formation and its crosstalk with pericyte and microglia to aggravate diabetes-induced microvascular dysfunction. FTO mediates DR phenotypes via regulating
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Full text @ EMBO Mol. Med.