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ZDB-FIG-230508-24

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Cao et al., 2022 - Nox4 promotes osteoblast differentiation through TGF-beta signal pathway

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Fig. 3

Fig. 3. Bone mineralization in nox4 −/− zebrafish is disrupted during early development. (A, C, E) WT and nox4 −/− zebrafish were stained with alizarin red at 9, 15, and 30 days postfertilization (dpf). Dorsal and lateral views of representative larvae are shown. The red arrows illustrate changes in bone growth.(B, D, F) Quantification of the alizarin red-stained area at 9, 15, and 30 dpf. (G) μCT analysis of WT and nox4 −/− zebrafish at 60 dpf. (H) Bone parameters in WT and nox4 −/− zebrafish. PS: parasphenoid bone; OC: occipital bone; N: notochord; OP: operculum; O: otolith; BV/TV: bone volume fraction; BS/BV: bone surface area to bone volume; Tb.Th: trabecular thickness; Tb.Sp: trabecular separation. The scale bars in panels A, C, E are 200 μm,and in panels G is 500 μm n = 10. The data were analyzed using one-way ANOVA. *P < 0.05, **P < 0.01, and ***P < 0.001. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)

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Reprinted from Free radical biology & medicine, 193(Pt 2), Cao, Z., Liu, G., Zhang, H., Wang, M., Xu, Y., Nox4 promotes osteoblast differentiation through TGF-beta signal pathway, 595-609, Copyright (2022) with permission from Elsevier. Full text @ Free Radic. Biol. Med.