FIGURE

Fig. 6

ID

ZDB-FIG-220926-14

Publication

Zoodsma et al., 2022 - Disruption of grin2B, an ASD-associated gene, produces social deficits in zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Fig. 6

Nonsense-mediated decay and compensatory changes in NMDAR subunit expression in grin2B^?/?. A Relative rt-qPCR expression levels at grin2Ba at 3 dpf (n = 4, 4) and 5 dpf (n = 4, 4; ***p = 3.5e?4) for wild-type controls and grin2Ba single mutants, respectively, and of grin2Bb at 3 dpf (n = 4, 4) and 5 dpf (n = 4, 4; *p = 0.037) for wild-type controls and grin2Bb single mutants, respectively. B Relative rt-qPCR expression levels at 3 dpf of grin1a (n = 4, 4; *p = 0.013), grin1b (n = 4, 4; ***p = 9.4e?4), grin2Aa (n = 4, 4), grin2Ab (n = 4, 4; *p = 0.026), grinCa (n = 4, 4), grinCb (n = 4, 4), grinDa (n = 4, 4), and grinDb (n = 4, 4; *p = 0.041) for wild type and grin2B^?/?, respectively. C Relative rt-qPCR expression levels at 3 dpf of grin1a (n = 9, 9; *p = 0.013), grin1b (n = 8, 8; *p = 0.033), grin2Aa (n = 7, 7), grin2Ab (n = 8, 8; **p = 0.0061), grinCa (n = 4, 4), grinCb (n = 4, 4), grinDa (n = 11, 10; **p = 0.0018), and grinDb (n = 11, 11; ***p = 1.5e?4) for wild type and grin2B^?/?, respectively

Expression Data

Genes:	grin1a grin1b grin2ab grin2ba grin2bb grin2da grin2db
Fish:	grin2bb^{sbu311/sbu311} grin2ba^sbu310/+ grin2ba^{sbu310/sbu310}; grin2bb^{sbu311/sbu311}
Anatomical Term:	whole organism
Stage Range:	Protruding-mouth to Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	grin2ba^{sbu310/sbu310} grin2bb^{sbu311/sbu311} grin2ba^sbu310/+ grin2ba^{sbu310/sbu310}; grin2bb^{sbu311/sbu311}
Observed In:	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay whole organism
Stage Range:	Protruding-mouth to Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Mol Autism