Gene
grin2da
- ID
- ZDB-GENE-041008-124
- Name
- glutamate receptor, ionotropic, N-methyl D-aspartate 2D, a
- Symbol
- grin2da Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to have NMDA glutamate receptor activity and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in excitatory postsynaptic potential; glutamatergic synaptic transmission; and long-term synaptic potentiation. Predicted to localize to NMDA selective glutamate receptor complex and postsynaptic density membrane. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 46. Is expressed in presumptive neural retina; retina; and somite. Orthologous to human GRIN2D (glutamate ionotropic receptor NMDA type subunit 2D).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7137805 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 46 | Alliance | Developmental and epileptic encephalopathy 46 | 617162 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001320 | Ionotropic glutamate receptor, C-terminal |
| Domain | IPR001828 | Receptor, ligand binding region |
| Domain | IPR019594 | Ionotropic glutamate receptor, L-glutamate and glycine-binding domain |
| Family | IPR001508 | Ionotropic glutamate receptor, metazoa |
| Family | IPR015683 | Ionotropic glutamate receptor |
| Homologous_superfamily | IPR028082 | Periplasmic binding protein-like I |
Domain Details Per Protein
| Protein | Length | Ionotropic glutamate receptor | Ionotropic glutamate receptor, C-terminal | Ionotropic glutamate receptor, L-glutamate and glycine-binding domain | Ionotropic glutamate receptor, metazoa | Periplasmic binding protein-like I | Receptor, ligand binding region |
|---|---|---|---|---|---|---|---|
|
UniProtKB:I3NI77
|
1916 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
grin2da-201
(1)
|
Ensembl | 6,417 nt | ||
| mRNA |
grin2da-202
(1)
|
Ensembl | 10,596 nt |
Interactions and Pathways
No data available
Plasmids
No data available