Gene

grin1b

ID

ZDB-GENE-051202-2

Name

glutamate receptor, ionotropic, N-methyl D-aspartate 1b

Symbol

grin1b Nomenclature History

Previous Names

NMDAR1.2 (1)
si:rp71-1o1.1

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to contribute to NMDA glutamate receptor activity. Predicted to be involved in chemical synaptic transmission; ionotropic glutamate receptor signaling pathway; and regulation of membrane potential. Predicted to localize to NMDA selective glutamate receptor complex; neuron projection; and synapse. Human ortholog(s) of this gene implicated in alcohol use disorder; autosomal dominant non-syndromic intellectual disability 8; and cerebral infarction. Is expressed in brain. Orthologous to human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from 9 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Griffin et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With grin1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant intellectual developmental disorder 8	Alliance	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant	614254
developmental and epileptic encephalopathy 101	Alliance	Developmental and epileptic encephalopathy 101	619814
		Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive	617820

Associated With grin1b Via Experimental Models

Human Disease	Fish	Conditions	Citations
epilepsy	grin1b^s3020/+	standard conditions	Griffin et al., 2021

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001320	Ionotropic glutamate receptor, C-terminal
Domain	IPR001828	Receptor, ligand binding region
Domain	IPR019594	Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
Domain	IPR049872	Glutamate [NMDA] receptor subunit 1-like, ligand-binding domain
Domain	IPR049873	Glutamate [NMDA] receptor subunit 1-like, N-terminal LIVBP-like domain
Family	IPR001508	Ionotropic glutamate receptor, metazoa
Family	IPR015683	Ionotropic glutamate receptor
Homologous_superfamily	IPR028082	Periplasmic binding protein-like I